Isabella undertook her first official engagement, the baptism of a ferry-the M/F Princess Isabella operating between Jutland and Samso-named in her honor on 6 June 2015.

Isabella received the Lutheran rite of confirmation in the same chapel on 30 April 2022, which was presided over by Henrik Wigh-Poulsen, the Danish royal Chaplain-in-Ordinary. Her godparents were her father’s first cousin, Princess Alexia of Greece and Denmark Queen Mathilde of Belgium (then Duchess of Brabant), Nadine Johnston, Christian Buchwald, Peter Heering and Marie Louise Skeel. Her christening took place on 1 July 2007, at the Royal Chapel of Fredensborg Palace where her name, per Danish royal tradition, was revealed to be Isabella Henrietta Ingrid Margrethe, after the Danish queen consort and ancestress Isabella of Austria, the princess’s maternal grandmother, paternal great-grandmother, and paternal grandmother respectively.

At noon on 22 April, a 21-gun salute was fired from the Sixtus Battery at Holman Naval Base in Copenhagen and from Kronborg Castle in North Zealand to mark her birth Princess Isabella was born at Rigshospitalet, the Copenhagen University Hospital, in Copenhagen, to Crown Prince Frederik and Crown Princess Mary. Isabella is third in the line of succession to the Danish throne, after her father and her older brother, Prince Christian. She was the first girl born into the Danish royal family since the birth of her great aunt, Queen Anne-Marie of Greece, in 1946. She is the fourth grandchild and oldest granddaughter of Queen Margrethe II and the late Prince Henrik. She is the second child and elder daughter of Crown Prince Frederik and Crown Princess Mary. Princess Isabella of Denmark, Countess of Monpezat (Isabella Henrietta Ingrid Margrethe born 21 April 2007) is a member of the Danish royal family.